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In this issue:
🤝In Partnership: Answers from all your data
🤿Deep Dive: A dog got the first AI-designed personalized cancer vaccine
🎁Referral Rewards: Earn perks by inviting friends
🤿Deep Dive: Florida homeowner sold his house using only AI
🤝Powered by: The IT strategy toolkit for 2026
🤿Deep Dive: Atlassian's AI-driven layoffs
⚒Tool Snapshots: Tools for AI, no-code, and productivity
🖼AI Art: Examples of great and trending AI art
🤝IN PARTNERSHIP WITH FABI
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🤿 DEEP DIVE
Sydney Developer Uses AI to Design a Personalized mRNA Cancer Vaccine for His Dog
Intelligence: Sydney data scientist Paul Conyngham used ChatGPT, AlphaFold, and $3,000 worth of DNA sequencing to design a personalized mRNA cancer vaccine for his rescue dog Rosie after chemotherapy failed to shrink her tumors, working with UNSW's RNA Institute to manufacture and administer it, resulting in a roughly 75% reduction in her tumor within weeks and what researchers are calling the first personalized cancer vaccine ever designed for a dog.
UNSW researchers say the case demonstrates that mRNA vaccine technology is being democratized, with Conyngham having no biology background, and raises the direct question of why the same approach isn't being rolled out to human cancer patients, a question the pharma industry is already answering, with Moderna and Merck's jointly developed personalized melanoma vaccine showing a 49% reduction in recurrence or death risk over five years and Phase 3 trials now underway.
BioNTech's personalized mRNA cancer vaccine showed immune responses persisting for nearly four years in a Phase 1 pancreatic cancer trial, with responding patients showing delayed tumor recurrence, and a larger Phase 2 trial is now enrolling globally across multiple cancer types.
Moderna and Merck's melanoma vaccine could be priced similarly to Keytruda at around $200,000 per patient, with Jefferies analysts projecting multibillion-dollar peak sales in melanoma alone before accounting for lung, kidney, and bladder cancer programs also in trials.
More than 400 cancer vaccine trials have been initiated globally in the last three years, roughly 120 of which are testing mRNA-specific approaches, across a broader mRNA therapeutics market valued at $7.7 billion in 2025 and expected to grow significantly as oncology programs advance.
🎁REFERRAL REWARDS
If TIW has been useful, invite one friend or coworker who’d actually use AI/automation at work.
1 referral → get the TIW No-Code Workflows PDF (25 plug-and-play workflows)
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Tip: send it to a friend who’s AI-curious, a coworker who wants to move faster, or anyone trying to automate repetitive tasks.
🤿 DEEP DIVE
Robert Levine Uses ChatGPT for Every Step of His Home Sale, and Sold His House in 5 Days
Intelligence: Florida homeowner Robert Levine used ChatGPT to handle nearly every step of selling his Cooper City home. Pricing strategy, curb appeal recommendations, marketing materials, MLS listing, showing coordination, and contract drafting, receiving five offers within 72 hours of listing and signing a contract within 5 days, while estimating savings of roughly 3% of the total sale price by bypassing a traditional agent.
Levine hired a lawyer only to review legal documents, framing the experiment not as a replacement for real estate agents but as a demonstration of how AI tools are becoming a meaningful and accessible part of the home-selling process for buyers willing to invest time in learning them.
ChatGPT provided the most immediate value through a structured sale timeline, telling Levine exactly when to start packing, when to list, and which day of the week would maximize early offer volume, replacing the strategic guidance traditionally provided by an experienced agent.
Room repaints recommended by ChatGPT for maximum ROI, a Tuesday listing date, and AI-generated open house materials all contributed to a sale that exceeded Levine's expectations before the scheduled open house even took place.
🤝POWERED BY DEEL
The IT strategy every team needs for 2026
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🤿 DEEP DIVE
Atlassian Cuts Around 1,600 Roles to Accelerate Investment in AI
Intelligence: Atlassian announced it is cutting 10% of its workforce, approximately 1,600 employees, to redirect resources toward AI investment, enterprise sales, and financial strengthening, with CEO Mike Cannon-Brookes framing the decision as a proactive response to a higher bar for what software companies must deliver on growth, profitability, speed, and value creation.
The move follows Block CEO Jack Dorsey's February announcement of more than 4,000 cuts, nearly half of Block's workforce, citing AI automation as the direct driver, with Dorsey predicting many other companies would reach the same conclusion.
Atlassian declined to specify which roles were cut or detail its post-layoff structure, but positioned the reduction as a strategic reallocation rather than a sign of financial distress, framing it as choosing to adapt ahead of market pressure rather than reacting to it.
The back-to-back announcements from Atlassian and Block signal an accelerating pattern among established tech companies of using AI investment as the stated justification for headcount reductions, normalizing workforce restructuring as a standard response to AI's expanding operational role.
⚒ TOOL SNAPSHOTS
Futuristic tools within AI, no-code, and productivity
🖥️ DynamicLake - Streamline your Mac experience with versatile tools & features.
💼 Google Workspace CLI - Streamline & automate your Google tools control.
🛡️ ClawSecure - Real-time, 3-layer security for OpenClaw AI agents
🎬 ElevenCreative - Generate & edit premium audio/video instantly.
📅 Cal.com Agents - AI-powered scheduling across multiple platforms.
🖼 AI ART
Examples of great and trending AI art
Images by Sharp_Alternative845
https://www.reddit.com/r/midjourney/comments/1rudueb/red_cliff_park/
ℹ️ ABOUT US
The Intelligent Worker helps you to be more productive at work with AI, automation, no-code, and other technologies.
We like real, practical, and tangible use-cases and hate hand-wavy, theoretical, and abstract concepts that don’t drive real-world outcomes.
Our mission is to empower individuals, boost their productivity, and future-proof their careers.
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